Nerolidol

Nerolidol (3,7,11-trimethyl-1,6,10-dodecatrien-3-ol; C₁₅H₂₆O) is a sesquiterpene alcohol occurring as (E)- and (Z)-isomers, found in neroli (bitter orange blossom), ginger, jasmine, and tea tree. In cannabis it is generally a minor terpene contributing woody-floral aromas. Preclinical studies document antiparasitic activity against Leishmania, Plasmodium, and Trypanosoma (Arruda et al., 2005, Acta Tropica 96:10), antifungal effects, and sedative/anxiolytic activity in rodent models. Nerolidol is a potent skin-penetration enhancer, widely used in transdermal drug delivery research (Williams & Barry, 2004, Advanced Drug Delivery Reviews 56:603). Evidence level: rodent and in vitro; no human cannabis-specific data. → See also: Terpene, Terpenoid.